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. Author manuscript; available in PMC: 2013 Oct 25.
Published in final edited form as: Semin Thromb Hemost. 2011 Nov 18;37(5):10.1055/s-0031-1281039. doi: 10.1055/s-0031-1281039

Table 3.

VWD diagnosis by type

VWD diagnosis Laboratory findings
Type 1 ↓ (but proportional) VWF:Ag and VWF:RCo with normal multimers
Type 1C ↓ VWF:Ag with ↑ VWFpp/VWF:Ag ratio
Type 2A ↓ VWF:RCo/VWF:Ag ratio with abnormal multimers
Type 2B ↓ VWF:RCo/VWF:Ag ratio with abnormal multimers and ↑ LD-RIPA, abnormal VWF:PB, possible thrombocytopenia
Type 2M ↓ VWF:RCo/VWF:Ag ratio with normal multimers
Type 2N ↓ FVIII:C/VWF:Ag and abnormal VWF:FVIIIB
Type 3 Absent VWF:Ag and VWF:RCo

Abbreviations: VWF:Ag=VWF antigen; VWF:RCo=VWF ristocetin cofactor activity; FVIII:C=factor VIII activity; multimers=multimer distribution analysis; LD-RIPA=low dose ristocetin-induced platelet aggregation; VWF:PB=VWF-platelet binding; VWF:FVIIIB=VWF-FVIII binding; VWFpp=VWF propeptide.