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Crystal-structure binding modes of four of the identified inhibitors bound to BRD4(1). The left panel gives an overview of the binding mode. The right panel gives a through-protein view highlighting the binding mode of each KAc mimetic. Surface colors were generated using the pocket colors in MOE. Green represents an enclosed surface, and white, exposed. (A) Compound 1, (B) compound 3, (C) compound 4, and (D) compound 5.
