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. 2013 Oct 2;2013:849754. doi: 10.1155/2013/849754

Figure 4.

Figure 4

Paclitaxel- (PTX-) induced mechanical allodynia with or without Goshajinkigan (GJG) administration in mice with breast cancer. PTX (10 and 20 mg/kg) and vehicle (VH1) were injected intraperitoneally, and GJG (1 g/kg) and vehicle (VH2) were administered orally, as described in Figure 1 legend. The evaluation of pain-related responses using a von Frey filament was performed before drug administration every day. (a) The site of allodynia evaluation. ((b), (c)) Time-course of allodynia induced by PTX administration (b) with or (c) without GJG administration. Values represent the means ± SEM. Figures in parentheses indicate the number of animals. (b) Main effect of PTX treatment, F 2,312 = 8.922, P = 0.004; interaction between PTX treatment and time, F 48,312 = 2.505, P < 0.001 (two-way repeated measures ANOVA).