Fig 2.

PML represses MHV68 reactivation and persistent infection. (A) Ex vivo reactivation from latency. Limiting-dilution ex vivo reactivation of virus in intact splenocytes and peritoneal exudate cells (PECs) from PML^−/− and PML^+/+ mice at 42 days postinoculation. Each sample contained pooled cells from four infected mice. (B) Parallel samples from PECs in panel A were mechanically disrupted prior to culture to detect preformed virus. In both panels, the data are presented as means ± standard deviations of three independent experiments.