Structure-based sequence alignment of CNV and TBSV using the alignment tools on the PDB server (28). (A) Stereo ribbon diagram of CNV color coded as per the various regions of the capsid protein. The arm, shell, hinge, and protruding domains are shown in green, blue, orange, and gray, respectively. (B) The primary sequences of CNV and TBSV aligned as per the atomic structure. In both panels, the putative calcium and zinc binding residues are highlighted in orange and mauve, respectively.