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Demyelination in the CNS of mice that received rIL-2 by microosmotic pumps implanted in the sidea
| Treatment | No. of mice with demyelination/total no. of mice tested (%) |
||
|---|---|---|---|
| Brain | SC | ON | |
| rIL-2 protein + HSV-1 | 2/7 (28) | 4/7 (57) | 0/0 |
| rIL-2 protein | 0/0 | 0/0 | 0/0 |
| HSV-1 | 0/0 | 0/0 | 0/0 |
Microosmotic pumps delivering rIL-2 were implanted subcutaneously into the side of C57BL/6 mice, and 14 days later the mice were ocularly infected with HSV-1 strain McKrae. Demyelination was assessed at 14 days p.i.
