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. 2013 Nov 15;208(Suppl 2):S137–S144. doi: 10.1093/infdis/jit447

Figure 3.

Figure 3.

Behavior of HIV-infected T cells in lymph nodes of BLT-humanized mice. A, Infected T cells migrate at reduced speeds, but effectively roam the lymph node cortex. B, Env-dependent adhesion causes tethering to unidentified CD4+ lymph node cells. C, Motile multinucleated syncytia alternate between coordinated and uncoordinated migration. The latter leads to the transient formation of long membrane processes that connect the individual nuclei. Abbreviations: BLT, bone marrow-liver-thymus; HIV, human immunodeficiency virus.

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