Figure 3.
Behavior of HIV-infected T cells in lymph nodes of BLT-humanized mice. A, Infected T cells migrate at reduced speeds, but effectively roam the lymph node cortex. B, Env-dependent adhesion causes tethering to unidentified CD4+ lymph node cells. C, Motile multinucleated syncytia alternate between coordinated and uncoordinated migration. The latter leads to the transient formation of long membrane processes that connect the individual nuclei. Abbreviations: BLT, bone marrow-liver-thymus; HIV, human immunodeficiency virus.