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. Author manuscript; available in PMC: 2014 Aug 19.
Published in final edited form as: ACS Macro Lett. 2013 Aug 19;2(9):10.1021/mz400229m. doi: 10.1021/mz400229m

Scheme 1.

Scheme 1

Synthetic route for the preparation of alkyne-functionalized PBYP49-b-PLLA44, 2, by one pot-sequential ROP, followed by post-polymerization modifications via thiol-yne “click”-reactions using either 3-mercaptopropionic acid or 2-aminoethanethiol to prepare aPPE49-b-PLLA44, 3, and cPPE49-b-PLLA44, 4, respectively, and finally, schematic illustration of the assembly of 3 and 4 into spherical micelles by direct dissolution in water to afford anionic and cationic micelles, 5 and 6, respectively (aPPE = anionic PPE and cPPE = cationic PPE).