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Aβ diurnal patterns diminish with increased age. The diurnal amplitude of Plasma Aβ40 (A), Plasma Aβ42 (B), CSF Aβ40 (C), and CSF Aβ42(D) were decreased by approximately half in the older groups (Amyloid − and Amyloid +) compared to the younger group, regardless of amyloid deposition. Data are group averaged mean-adjusted Aβ levels over time.
