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. Author manuscript; available in PMC: 2013 Oct 25.
Published in final edited form as: J Cancer Ther. 2013 May;4(3):10.4236/jct.2013.43094. doi: 10.4236/jct.2013.43094

Figure 1.

Figure 1

MALAT-1 promoter activity and transcript levels correlate with p53 activity. A. Several consensus binding sites were detected upstream of the MALAT-1 start site, including five p53 binding sites (green), three T antigen binding sites (red), two TCF-2 binding sites (purple), and two E2F-1 binding sites (blue). B. Representative data showing significantly increased MALAT-1 promoter activity in p53-deficient SAOS cells 72 hours after transfection with p53-expressing constructs. C. Representative levels of MALAT-1 expression in different cell types with or without p53 gene expression, presented as the change (n-fold) in MALAT-1 transcript levels (level in OKF6 cells arbitrarily set to 1).