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. 2013 Jun 18;21(10):1919–1929. doi: 10.1038/mt.2013.135

Figure 4.

Figure 4

Intravenous administration of LPH(CD47) NP inhibited B16F10 solid tumor growth. (a) IV injection LPH(CD47) NP inhibited B16F10 tumor growth. Tumor n = 5–7 per group, error bars show mean ± SEM (**P < 0.01, ***P < 0.0001 one-way analysis of variance). (b) Images of representative of tumors collected from the endpoint of the experiment. (c) Immunofluorescence staining of CD47 on tumor tissues collected. The nucleus was stained with DAPI and CD47 was stained with FITC-conjugated, anti-CD47 antibody. (d) Western-blot analysis of CD47 protein level in the tumors after treatment. (e) Quantitation of CD47 mRNA level in the tumors after treatment (Student's t-test, **P < 0.01, ***P < 0.001).