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Intravenous administration of LPH(CD47) NP inhibited the growth of B16F10 lung metastasis. (a) Images of B16F10 metastasis bearing lung harvested on day 18 after inoculation. (b) Quantitation of tumor load on the lung lobe determined by luciferase activity (n = 5) (Student's t-test, *P < 0.05, ***P < 0.001). (c) Representative images of hematoxylin and eosin staining of the lung tissues harvested from treated animals. Arrows indicate micrometastases in the lung tissue.
