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LV-CD11b corrects lysosomal compartment size in MPSIIIA brains. Representative confocal images of (a) brain cortex (layer IV/V) and (b) amygdala (medial nucleus) from approximately −1.18 mm relative to bregma were stained with LAMP2 for lysosomal compartment (green) and NeuN for neuronal nuclei (red), and representative images are shown. Bar = 20 µm. LV, lentiviral vector; MPSIIIA, mucopolysaccharidosis type IIIA; PGK, phosphoglycerate kinase; WT, wild-type.
