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. 2013 Jul 16;21(10):1938–1949. doi: 10.1038/mt.2013.141

Figure 6.

Figure 6

LV-CD11b and LV-PGK both correct secondary storage and presynaptic vesicles in the cerebral cortex, while LV-PGK is less effective in the amygdala of MPSIIIA mice. Four brain sections per mouse (n = 5 per group), taken from approximately bregma 0.14, −0.58, −1.3, and −2.06 mm, were stained and quantified for GM2 ganglioside in the (a) cerebral cortex and (b) amygdala, and VAMP2 for presynaptic vesicles in the (c) cerebral cortex and (d) amygdala. Representative images from the cerebral cortex (layer IV/V) and the amygdala, both from approximately −1.3 mm relative to bregma, are shown. Error bars represent the SEM. Significant differences to MPSIIIA, between the two groups marked with a line, are demonstrated with ***P < 0.001. Bar = 50 µm. LV, lentiviral vector; MPSIIIA, mucopolysaccharidosis type IIIA; PGK, phosphoglycerate kinase; WT, wild-type.