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Downregulation of Notch signaling inhibits CPC cardiovascular differentiation. CPCs were isolated from infarcted hearts in the absence (-) and in the presence (+) of DAPT treatment, 3 days following MI and HMGB1 administration. qRT-PCR was performed to detect the expression of myocardial (Tbx5), endothelial (Tie2) and smooth muscle (smMHC) cell markers. n = 3, *,†P < 0.05 versus each control.
