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High magnification EM images of VGLUT2+ immunolabeled synaptic terminals on dendrites of striatal neurons from 1 month- (A, B), 4 month- (C, D), and 12 month-old (E, F) wildtype (A, C, E) and heterozygous Q140 Huntington’s disease knock-in (B, D, F) mice. Dendrites (De) were recognizable by their larger size, the presence of mitochondria (M) and microtubules, and the absence of spine apparatus. Arrow indicates postsynaptic density (PSD). All images are at the same magnification.
