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EM images of VGLUT2+ immunolabeled synaptic terminals in striatum of 1 month- (A, B), 4 month- (C, D), and 12 month-old (E, F) wildtype (A, C, E) and heterozygous Q140 Huntington’s disease knock-in (B, D, F) mice. The relatively low power views show many labeled terminals, and typify the shortfall in VGLUT2 terminals seen in Q140 mice at all ages. All images are at the same magnification.
