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. Author manuscript; available in PMC: 2013 Oct 25.

Published in final edited form as: Lab Invest. 2012 Mar 12;92(5):713–723. doi: 10.1038/labinvest.2012.45

Fig. 3 — (A-D) RT-PCR analysis of HSC activation markers transforming growth factor beta (TGFβ), collagen type I alpha 1 (COL1A1), alpha smooth muscle actin (αSMA), cysteine- and glycine-rich protein 2 (CRP2), mRNA expression in liver of Casp1^−/− mice compared to WT mice (n = 5-7 in each group). (E) Western blot of αSMA on whole liver lysates in WT and Casp1^−/− MCD-fed mice compared to CTL-fed mice and (F) corresponding densitometric analysis to HSC70 (n=3). (G) Collagen fibers were stained with Sirius red and (H) quantified using the surface area stained per 40x field area (n = 5-7 in each group) excluding blood vessels. Results are expressed as mean ± S.E.M. * P < 0.05; ** P < 0.01; ***P < 0.001 compared to controls.

Fig. 3 — (A-D) RT-PCR analysis of HSC activation markers transforming growth factor beta (TGFβ), collagen type I alpha 1 (COL1A1), alpha smooth muscle actin (αSMA), cysteine- and glycine-rich protein 2 (CRP2), mRNA expression in liver of Casp1^−/− mice compared to WT mice (n = 5-7 in each group). (E) Western blot of αSMA on whole liver lysates in WT and Casp1^−/− MCD-fed mice compared to CTL-fed mice and (F) corresponding densitometric analysis to HSC70 (n=3). (G) Collagen fibers were stained with Sirius red and (H) quantified using the surface area stained per 40x field area (n = 5-7 in each group) excluding blood vessels. Results are expressed as mean ± S.E.M. * P < 0.05; ** P < 0.01; ***P < 0.001 compared to controls.