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Functional interplay between WT and mutant Ras. Shown in this figure are the signaling interactions between mutationally activated K-Ras and WT H-Ras and N-Ras. Similar interactions are also seen human tumor cells harboring mutated H-Ras or N-Ras and the remaining two WT Ras isoforms. siRNA silencing of either mutant (*) KRAS or concurrently WT HRAS and NRAS reduces tumor cell proliferation.
