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. 2013 Oct 25;8(10):e78814. doi: 10.1371/journal.pone.0078814

Figure 4. Dose-dependent effects of Tenofovir on the expression of MIP3α, IL-8 and TNFα genes in macrophages.

Figure 4

Monocyte-derived macrophages (macrophages) were treated with different concentrations of TFV (1, 0.5, 0.1, 0.01, 0.01 and 0.001 mg/ml) for 2, 12 and 24hr. Bars represent mean ± SEM from 4 separate experiments with different donors. *P<0.05 **P<0.01. (A) Macrophage expression of MIP3α gene in presence of different concentrations of tenofovir at 2, 12 and 24hr. (B) Macrophage expression of IL-8 gene in presence of different concentrations of tenofovir at 2, 12 and 24hr. (C) Expression of TNFα gene in presence of different concentrations of tenofovir at 2, 12 and 24hr.