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. 2013 Oct 25;8(10):e78814. doi: 10.1371/journal.pone.0078814

Figure 5. Time dependent effects of Tenofovir on the expression of MIP3α, IL-8 and TNFα genes in macrophages, dendritic cells and resting and activated CD4+ T cells.

Figure 5

Macrophages and DCs were treated with 1mg/ml of TFV for 2 to 24hr. CD4+ resting and activated T cells were treated with 1mg/ml of TFV for 2, 12 and 24hr. Bars represent mean ± SEM from 3-4 independent experiments with different donors. *P<0.05 **P<0.01. (A) Macrophage expression of MIP3α, IL-8 and TNFα genes at different time points (B) DC expression of MIP3α, IL-8 and TNFα genes at different time points. (C) Expression of IL-8 gene at 2, 12 and 24hr in resting CD4+ T cells. (D) Activated CD4+ T cells expression of IL-8 gene at 2, 12 and 24hr.