Figure 4. A. A lower dose of cabozantinib at 30 mg/kg also inhibits tumor progression as demonstrated by decreases in serum PSA in animals bearing LuCaP 23.1 tumors in the tibiae.

The lower dose was well tolerated for 6 weeks of treatment with no significant body weight loss. Prolonged treatment (7–15 weeks) caused 7–11% body weight decreases which were, however, statistically significant (P=0.0002-0.04). Significance of the changes was determined by comparing enrollment BW to BW at each week using 2-sided t-test. Mean ± SEM is plotted. B. Cabozantinib treatment (60 mg/kg) inhibited tumor growth of subcutaneous castration-resistant C4-2B tumors as determined by TV and serum PSA levels. This treatment also significantly increases survival as determined by log-rank test. C4-2B tumor growth causes decreases of BW in the experimental animals (4–13%, P= 0.0001-0.003), and the cabozantinib treatment prevents this effect resulting in no significant BW loss. Significance of the changes was determined by comparing enrollment BW to BW at each week using 2-sided t-test. Mean ± SEM of the group is plotted.