Figure 1. TvGM6 is a homolog of the protein found in other trypanosomes, is conserved within T, vivax isolates and is flagellar associated.

(A) Alignment of the GM6 repeat motif from T. brucei brucei (427), T. congolense (IL3000) and T. vivax (Y486). (B) Sequence alignment of a single repeat of the TvGM6 sequence from T. vivax isolates originating from Burkina Faso (BF) and Ethiopia (ET). The T. vivax Y486 reference strain is shown. Background colour indicates conservation (black), similarity (grey) and differences (white) in amino acid sequence. (C) Immunofluorescence microscopy of T. vivax Y486 bloodstream forms showing partial co-localisation of anti-TvGM6 antibodies (green) with anti-paraflagellar rod (PFR) antibodies (red).