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. 2013 Oct 25;8(10):e78099. doi: 10.1371/journal.pone.0078099

Figure 4. IL-33, but not IL-25, is required for IL-5 production, but not Th2 cell differentiation, during HDM-induced AR in mice.

Figure 4

(A, B) HDM-specific LN cell proliferative responses and cytokine production of wild-type and IL-25−/− mice (A) and of wild-type and IL-33−/− mice (B) 48 hours after the last inhalation of HDM or PBS. Data show the mean + SEM (PBS, n = 3–4; HDM, n = 6–7), and the results generated in one of two independent experiments, each of which gave similar results. * P<0.05. (C–F) The proportion of cytokine-producing CD3+ CD4+ T cells in cervical LN cells cultured with and without HDM in vitro, as in (A) and (B). (C, E) FACS data show the results for LN cells pooled from 5 mice in each group, and a representative result of 5 independent experiments. (D, F) Data show the mean + SEM of 5 independent experiments in (C) and (E). Med =  Medium alone.