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. 2013 Oct 25;8(10):e78481. doi: 10.1371/journal.pone.0078481

Figure 1. Pedigree of a novel Italian NB family with ALK mutations.

Figure 1

Family includes three affected children, two siblings and a first cousin indicated by filled symbol. Patient III-1 has an adrenal NB at stage 4S of disease. Patient III-2 was affected by a stage 3 NB in abdominal paravertebral region. Patient III-3 had a stage 4 adrenal NB with multiple subcutaneous lesions. All family members with DNA available for genotyping are indicated with either wild type (wt) for ALK, or with mutation in the ALK tyrosine kinase domain (R1192P). Stage of disease and morphologic tumor classification are listed according to the INSS and the INPC, respectively. Age: age at diagnosis; m: months; wt: wild-type in the ALK gene, R1192P: R1192P mutation in the ALK gene.