Table 2. Characteristics of HBeAg-positive and HBeAg-negative patients with PNALT stratified by ALT and age.
| HBeAg-positive |
HBeAg-negative |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ALT≤0.5× ULN |
ALT 0.5- 1×ULN |
P Value |
Age≤30 | Age>30 | P Value |
ALT≤0.5× ULN |
ALT 0.5- 1×ULN |
P Value |
Age≤40 | Age>40 | P Value |
|
| (n = 14) | (n = 71) | (n = 77) | (n = 8) | (n = 23) | (n = 32) | (n = 46) | (n = 9) | |||||
| Age | 23.3±3.7 | 23.6±6.5 | NS | ( - ) | ( - ) | ( - ) | 36.2±7.7 | 34.8±6.8 | NS | ( - ) | ( - ) | ( - ) |
| Male | 5 (35.7%) | 40 (56.3%) | NS | 41 (53.2%) | 4 (50.0%) | NS | 6 (26.1%) | 22 (68.8%) | 0.002 | 24 (52.2%) | 4 (44.4%) | NS |
| PLT (×109/L) | 211.0±59.0 | 212.5±57.7 | NS | 214.3±58.7 | 192.5±43.3 | NS | 227.0±83.9 | 199.8±52.0 | NS | 208.8±64.1 | 223.2±88.0 | NS |
| PTA (%) | 102.2±12.9 | 103.6±18.4 | NS | 103.1±17.2 | 105.8±22.0 | NS | 106.5±17.4 | 106.0±20.2 | NS | 104.6±18.1 | 114.2±22.0 | NS |
| ALB (g/L) | 43.8±3.2 | 45.6±3.5 | NS | 45.4±3.4 | 43.3±3.8 | NS | 44.4±3.8 | 44.7±4.5 | NS | 44.9±4.0 | 42.6±4.5 | NS |
| ALT (U/L) | ( - ) | ( - ) | ( - ) | 27.0±6.8 | 27.5±6.3 | NS | ( - ) | ( - ) | ( - ) | 23.4±7.8 | 25.8±8.9 | NS |
| AST (U/L) | 21.6±2.9 | 24.9±4.6 | 0.004 | 20.7±4.0 | 22±4.0 | NS | 20.8±4.0 | 26.1±5.8 | <0.001 | 23.7±5.4 | 25.2±7.4 | NS |
| HBV DNA (log10 copies/mL) | 7.25±0.67 | 7.61±0.69 | NS | 7.55±0.71 | 7.58±0.62 | NS | 3.17±0.43 | 3.25±0.50 | NS | 3.21±0.46 | 3.20±0.52 | NS |
| Undetectable HBV DNA | ( - ) | ( - ) | ( - ) | ( - ) | ( - ) | ( - ) | 9 (39.1%) | 12 (37.5%) | NS | 18 (39.1%) | 3 (33.3%) | NS |
| Inflammation grade | ||||||||||||
| <A2 | 14 (100%) | 70 (98.6%) | NS | 76 (98.7%) | 8 (100%) | NS | 23 (100%) | 27 (84.4%) | NS | 41 (89.1%) | 9 (100%) | NS |
| ≥A2 | 0 (0%) | 1 (1.4%) | 1 (1.3%) | 0 (0%) | 0 (0%) | 5 (15.6%) | 5 (10.9%) | 0 (0%) | ||||
| Fibrosis stage | ||||||||||||
| <F2 | 6 (42.9%) | 37 (52.1%) | NS | 42 (54.5%) | 1 (12.5%) | 0.058 | 19 (82.6%) | 19 (59.4%) | NS | 32 (69.6%) | 6 (66.7%) | NS |
| ≥F2 | 8 (57.1%) | 34 (47.9%) | 35 (45.5%) | 7 (87.5%) | 4 (17.4%) | 13 (40.6%) | 14 (30.4%) | 3 (33.3%) | ||||
Parameters are expressed as mean±SD or number (%)
PNALT, persistent normal ALT; PLT, platelet; PTA, prothrombin activity; ALB, albumin; ALT, alanine aminotransaferase; AST, aspirate aminotransferase; ULN, upper limit of the normal range; NS, not significant
The normal range of ALT and AST are 5-40 U/L, PLT is 100-300 ×109/L, ALB is 35-55 g/L