Table 1. Characteristics of eligible studies in the meta-analysis (ACE I/D).

		HCM				Control
		Genotypes				Genotypes				HWE in control
First author, Year	Country	N	II	ID	DD	N	II	ID	DD	P value	Control subjects	Mean age in Case (years)	Mean age in Control (years)
Kawaguchi 2003	Japan	80	26	41	13	88	43	28	17	0.0045	Unaffected siblings and children	/	/
Coto 2010	Spain	207	35	100	72	300	46	135	119	0.4527	Ethnic-matched (Caucasian)	/	51±17
Yamada 1997	Japan	71	31	32	8	122	50	55	17	0.7640	Healthy individuals	59.1±10.3	60.2±11.0
Marian 1993	USA	100	7	49	44	106	22	46	38	0.2495	Normal relatives	/	/
Pfeufer 1996	Germany	50	26	24	50	36			14	Yes	Age and gender matched unrelated healthy subjects	55±15	48±17
Kaya 2010	Turkey	63	8	34	21	20	5	9	6	0.6620	Ethic-matched healthy controls	55.94±14.8	53.9±7.9
Rai 2008	India	118	11	63	44	164	47	87	30	0.3532	Healthy,age,sex,and ethnicity matched controls	/	/
Ogimoto 2002	Japan	138	53	64	21	205	83	95	27	0.9821	Healthy Japanese	63±13	70±9
Doolan 2004	Austrilia	36	10	14	12	200	48	94	58	0.4150	Age and gender matched control population	49.17±20.56	/
Moiseev 1997	Russia	13	2	5	6	168	33	55	80	0.2445	Normal subjects	31.5±9.1	45.4±11.5
Lopez-Haldon 1999	Spain	40	2	13	25	269	33	125	111	0.8097	Healthy subjects	44.3±15.9	/

Note, HCM; hypertrophic cardiomyopathy; HWE, Hardy Weinberg Equilibrium.