Table 1. Seasonal variations in the eight time series between summer and winter.

	Mean in winter (sd)	Mean in summer (sd)	Proportion of increase	p value, Mann-Whitney's test
Fosfomycin and sulfamethizole sales in France# (2000–2012)	62.2 (10.9)	74.4 (13.0)	20%	<0.001
Google searches* (2004–2011)
France	53.7 (13.4)	61.7 (14.1)	15%	<0.001
USA	77.0 (7.0)	84.6 (6.4)	10%	<0.001
Germany	50.3 (12.7)	54.2 (10.9)	8%	<0.001
Italy	59.5 (10.6)	70.7 (12.9)	19%	<0.001
China	54.2 (11.7)	62.7 (12.1)	16%	<0.001
Brazil	30.8 (10.7)	27.1 (5.6)	13%	0.003
Australia	55.5 (16.3)	53.2 (9.0)	4%	0.01

^#expressed as number of boxes per week per 100,000 inhabitants.

^*Google searches containing the terms cystitis and/or urinary tract infection. Each is rescaled between 0 and 100 by Google Trends internal processes at download.

sd = standard deviation.