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. 2013 Oct 25;8(10):e77730. doi: 10.1371/journal.pone.0077730

Figure 5. Total respiratory system resistance in Balb/mice exposed to either filtered air or 1 week of Ova (a) or Ova alone (b).

Figure 5

Statistical comparisons were made to determine the effect of Dex and the nanoparticle status on resistance and compliance at baseline and after inhalation of saline (vehicle) and serial low doses of methacholine (0.5, 1.0 and 2.0 mg/mL). In the OVA group, treatment with either Dex or its nanoparticle drug vehicle (NP) independently attenuated Rrs and AHR (*,**p<0.0001) down to air control levels at the highest dose of methacholine. Rrs was significantly lower in the Dex-NP treated animals across all time points (F = 2.57, P<0.05), which supports the notion that it was more efficacious in preventing the both the inflammatory and AHR changes typically seen in this model. Data from all eight treatment groups were analyzed simultaneously using 2-way ANOVA with Bonferroni correction for multiple comparisons.