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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Sleep Res. 2013 Oct;22(5):10.1111/jsr.12045. doi: 10.1111/jsr.12045

Figure 5.

Figure 5

Determination of the effects of 5-HT2A receptor antagonism by M100907 (0.3 mg/kg, IV) on amphetamine elicited dopamine release within the caudate nucleus. Amphetamine was administered intravenously at 0.3 (A) and 1.0 mg/kg (B) following pretreatment with M100907 (open symbols) or its vehicle (closed symbols). vehicle (closed symbols). The shaded area is the same as in Figure 4. Abscissae: Time expressed in minutes in reference to the administration of amphetamine and plotted on a linear scale. Ordinates: Extracellular concentration of dopamine within the caudate expressed as a percent change from baseline. An * indicates a significant difference from baseline assessed via Dunnett’s test. A # indicates a significant difference in dopamine levels between the pretreatments as assessed by a paired t-test.