Cellular pathways associated with (A) localized TMD and (B) TMD with widespread pain.
Genes shown in blue are significantly associated with case status with P<0.05. (A) HTR2-> ELK-SRF/GATA4 pathway. HTR2A – 5-hydroxytryptamine receptor 2A (OMIM 182135), HTR2C - 5-hydroxytryptamine receptor 2C (OMIM 312861), MAPK1 – mitogen-activated protein kinase 1 (OMIM 176948), MAP2K1 - mitogen-activated protein kinase 1 (OMIM 176872). (B) T-cell receptor -> CREBBP pathway. CAMK4 - calcium/calmodulin-dependent protein kinase IV (OMIM 114080), CALM2 - calmodulin 2 (OMIM 114182).