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Effect of aif-1 inactivation in a collagen-induced arthritis model. Wt (n = 9) and aif-1−/− (n = 6) mice were immunized with chicken collagen, as described in Methods. (a) Paw diameter was measured from 29 to 69 days after immunization using a microcaliper. (b) Disease activity was scored during the same time period, as described in methods. *, P<.0001 for genotype-dependent difference in paw thickness or disease activity.
