Threshold of the ratio of costs of the first measurement over the subsequent ones (κ*) above which it is advisable to take as many repeated measurements as possible in the LDD case under the basic scenario. Otherwise, if the ratio of costs is less than κ*, the optimal is to take ropt = 1. The basic scenario for the LDD response pattern assumes covariance structure CS(σ, ρ) for the response (θ = 0), no dropout (πm = 0), constant exposure prevalence (pej = pe, ∀j = 0, … , r) and CS(ρe) exposure correlation structure. The threshold takes the form . The column with constant value of κ* = 5 corresponds to a time-invariant exposure (ρe = 1).