Table 3.

Effect of θ in determining r_opt for the LDD response pattern assuming no dropout, a constant exposure prevalence, CS(ρ_e) exposure covariance structure and DEX(θ, ρ) response covariance structure. Exploration was constrained to κ ≤ 20 and ρ ∈ (0:05; 0:95). Each pair represents (max(r_opt); κ_min) where κ_min is an approximation to the minimum value of κ for which ropt is greater than 1 (over the range of ρ) and max(r_opt) is the maximum value of r_opt, which was always reached at the maximun explored value of κ (20) and the minimum explored value of ρ (0.05).

Intraclass correlation of exposure (ρe)
θ	0.1	0.5	0.6	0.7	0.8	0.9	1
0 (CS)	(∞, 60:5)	(∞, 11:2)	(∞, 9:2)	(∞, 7:7)	(∞, 6:6)	(∞, 5:7)	(∞, 5)
0.10	*	*	(18, 19)	(21, 14)	(23, 12)	(26, 10)	(30, 8)
0.20	*	*	*	*	(14, 16)	(15, 13)	(17, 10)
0.25	*	*	*	*	(11, 19)	(12, 15)	(14, 11)
0.30	*	*	*	*	*	(10, 17)	(12, 13)
0.40	*	*	*	*	*	*	( 8, 16)
≥ 0:50	*	*	*	*	*	*	*

^*r_opt = 1 for any combination of κ ≤ 20, ρ_e ≥ 0:1 and ρ ∈ (0:05; 0:95).