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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Pain. 2013 Aug 8;154(11):10.1016/j.pain.2013.07.041. doi: 10.1016/j.pain.2013.07.041

Figure 4.

Figure 4

Antinociceptive effect of SP-LC/A. A. Mice received BoNT/A-LC:SP (N=9) or PBS (N=3) by i.c.m were analyzed for their behavioral response at noxious temperature (46 °C) in the thermal operant system after 2 weeks of training at 37 °C and 46 °C alternatively. A* indicates p<0.05 in an unpaired t-test with Welch’s correction. B. Both the BoNT/A-LC:SP (N=8) and PBS group (N=8) were treated with Taxol and their behavior to a noxious temperature (46 °C) was measured with the thermal operant system for two weeks. After 2 weeks each mouse of the LC-SP group received 1μg of BoNT/A-LC:SP in 2μl i.c.m and each mouse in the PBS group received 2 μl of PBS i.c.m. After 48 hours both groups were tested for pain response in thermal operant system for up to two consecutive weeks. A* indicate P<0.05 and a ** indicates P<0.001 in a Repeated Measures One-Way ANOVA followed by Dunnett’s test. A ## indicates significant comparison in an unpaired t-test (P< 0.0001) between the BoNT/A-LC:SP and PBS treated group 2 days after the treatment.