. Author manuscript; available in PMC: 2014 Oct 24.

Published in final edited form as: J Phys Chem B. 2013 May 30;117(42):10.1021/jp4020965. doi: 10.1021/jp4020965

Table 1.

Barrier Active Compounds and their Mechanism of Action

Compound	Effect on Permeability	Mechanism of Action
Thrombin¹⁵	Increase	Formation of stress fibers to subsequently increase cell contraction
Histamine¹⁶	Increase	Increased intracellular Ca⁺⁺ and Myosin Light Chain Kinase(MLCK) induced contraction
Hydrogen Peroxide (H₂0₂)¹⁷	Increase	RhoA activation, MLCK induced contraction
Y27632⁸	Decrease	Cytoskeletal relaxation via Rho inhibition
Sphingosine-1phosphate (S1P)¹⁸	Decrease	Cadherin reorganization and cytoskeletal relaxation.
Hepatocyte Growth Factor (HGF)¹⁹	Decrease	Rac/Rho mediated cytoskeletal relaxation