Figure 3.
Changes of landscape topography of nine core node gene regulatory network of stem cell development at different binding/unbinding speeds ω when the activation regulation (class A activation, self-activation for both ES markers and differentiation markers) strength changes. We can see with binding/unbinding speed ω decreased, the bistable landscape gradually evolves to have multi-stable attractors. Parameters are specified as: k = 1 (degradation), XeqA = 600, XeqA = 2000, fR = 60 and fA = 10, 20, 30 separately for the first column, second column and third column.