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. 2013 Oct 7;110(43):17450–17455. doi: 10.1073/pnas.1304790110

Fig. 4.

Fig. 4.

Targeting autophagy in vivo improves tumor elimination by NK cells. (A) Control (NK+) and NK-depleted (NK−) C57BL/6 (Left) or BALB/c (Right) mice were engrafted with B16–F10 murine melanoma cells and 4T1 mammary carcinoma cells, respectively. Tumor growth in NK+ and NK− C57BL/6 (n = 7) and BALB/c (n = 10) mice was monitored using caliper measurements on the indicated days. Statistically significant differences in tumor volume are indicated by asterisks (*P < 0.05; **P < 0.005). (B) Autophagy-competent (BECN1+) or -defective (BECN1−) B16–F10 or 4T1 cells were injected s.c. (Left) or in the mammary fat pad (Right), respectively, in control (NK+) and NK-depleted (NK−) C57BL/6 (n = 7) and BALB/c (n = 10) mice. Tumor growth was monitored using caliper measurements on the indicated days. Statistically significant differences are indicated by asterisks (*P < 0.05).