Table 1.

Comparing pharmacokinetic parameter values of docetaxel solution and formulation following oral administration in minipigs

Oral formulation	Cmax (ng/mL)	AUC (h⋅ng/mL)	CL (L/h/kg)
Docetaxel solution*	97.6 ± 221†	797.7 ± 1,141†	4 ± 2.8†
Docetaxel formulation‡	817.9 ± 558†	7,923.1 ± 5,644†	0.4 ± 0.5†

^*Average pharmacokinetic parameter values (mean ± SD) following oral administration of 1.25 mg/kg of Taxotere in fasted minipigs, n = 6.

^†Cmax, AUC, and CL of 1 vs. 2: P < 0.03 significantly.

^‡Average pharmacokinetic parameter values (mean ± SD) following oral administration of docetaxel-loaded NCs embedded in microparticles in fasted minipigs, n = 6.