Table 2.
Comparing pharmacokinetic parameters values of docetaxel following i.v. and oral administration in rats
| Formulation | Route | Cmax (ng/mL) | AUC (h⋅ng/mL) | CL (L/h/kg) |
| Taxotere | i.v. | — | 1,822 ± 350 | 2.8 ± 0.5 |
| Docetaxel NCs | i.v. | — | 2,289 ± 468 | 2.3 ± 0.5 |
| Docetaxel NCs | Oral | 132 | 270.9 | 36.9 |
| Docetaxel solution + blank MPs | Oral | 16.2 ± 30.6 | — | — |
| Docetaxel formulation | Oral | 1,022 ± 237 | 6,448 ± 2,439 | 1.7 ± 0.6 |
Cmax of row 5 vs. 4: P = 0.0002 extremely significant. AUC of 5 vs.1 and 2: P < 0.01 very significant. CL of 5 vs.1 and 2: P > 0.05 ns. i.v. administration of Taxotere and docetaxel NCs (mean ± SD) at a dose of 5 mg/kg, oral administration of docetaxel NCs, docetaxel solution with blank MPs, and docetaxel formulation (mean ± SD) at a dose of 10 mg/kg in fasted rats, n = 4.