Table 1.
KSL-W/PLGA microspheres: composition of formulations and manufacturing parameters.
| Formulation | PLGA (mg) |
(CH2Cl2) (mL) |
KSL-W (mg) |
KSL-W Solvent |
PVA % (w/v) |
Stirring (°C) Time |
|---|---|---|---|---|---|---|
| A | 600 | 20 | 200 | 2 mL DIW* 0.1 mL Tween 20 |
0.35 | 25°C 30 m 40°C 1 hr |
| B | 600 | 20 | 200 | 4 mL DIW + 0.1 mL Tween 20 | 0.35 | 25°C 30 m 40°C 1 hr |
| C | 600 | 20 | 200 | 3 mL DIW + 0.1 mL Tween 20 | 0.35 | 25°C 30 m 40°C 1 hr |
*DIW: deionized water.