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. 2013 Nov;3(11):a014308. doi: 10.1101/cshperspect.a014308

Figure 4.

Figure 4.

Expression of MYC genes during mouse cerebellar development. At embryonic day E13.5, GNPs that migrate from the upper rhombic lip (URL) and form the external granule layer (EGL) and GABAergic neural progenitors in the cerebellar ventricular zone (VZ) express MYCN. MYC is found expressed in precerebellar neuron progenitors in the lower rhombic lip. At P7, whereas the GNPs in the EGL continue to express MYCN, the Purkinje cell layer, composed of Bergman glia and Purkinje cells, expresses MYCL and CD133/prominin-positive multipotent progenitors. At P21, all GNPs have exited cycle, no longer express MYCN but do express MXD (see Eisenman 2013), and have migrated through the Purkinje cell layer to reside as postmitotic neurons in the internal granule layer (IGL) that, like Purkinje cells, express MYCL (www.gensat.org; www.cdtdb.neuroinf.jp/CDT/Top.jsp; Allen Brain Atlas). CD133/prominin-positive multipotent progenitors are marked with a “MYC?” because this is suspected but not known. Prom1, prominin 1.