Table 2.
Known groups validity: the least-squares mean baseline SOBDA weekly score by mMRC and CGI-S response categories at visit 2
| Response categories | Patient-completed mMRC (n), LS mean SOBDA score (SE) | Clinician-completed mMRC (n), LS mean SOBDA score (SE) | CGI-S (n), LS mean SOBDA score (SE) |
|---|---|---|---|
| 0 | 12, 1.92 (0.19) | – | – |
| 0–1 | – | 12, 1.78 (0.20) | – |
| 1 | 103, 1.94 (0.07) | – | 19, 1.87 (0.16) |
| 2 | 138, 2.20 (0.06) | 200, 2.08 (0.05) | 236, 2.11 (0.05) |
| 3 | 65, 2.26 (0.08) | 117, 2.28 (0.06) | 78, 2.33 (0.08) |
| 4 | 22, 2.73 (0.14) | 10, 2.73 (0.22) | 5, 2.72 (0.31) |
Owing to the small number of 0 and 1 responses in the clinician-completed mMRC, these two categories were combined.
CGI-S, Clinician Global Impression of Dyspnoea Severity; LS, least squares; mMRC, modified Medical Research Council; SOBDA, Shortness of Breath with Daily Activities.