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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2013 Jul 31;272(3):10.1016/j.taap.2013.07.013. doi: 10.1016/j.taap.2013.07.013

Figure 11. Hypothetical role of NOX4 in the mechanism of action of Erlotinib.

Figure 11

Erlotinib induces the expression and activity of NOX4 resulting in ROS production. This ROS production results in cytotoxicity in HNSCC cells but also activates autophagy as a protective mechanism.