Skip to main content
. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Nat Rev Mol Cell Biol. 2013 Jun;14(6):10.1038/nrm3591. doi: 10.1038/nrm3591

Figure 3. Quiescent stem cells are poised for activation.

Figure 3

A proposed model of how the quiescent state of a stem cell constitutes a poised state for activation. Quiescent stem cells are actively regulated at the epigenetic, transcriptional and post-transcriptional level. The epigenetic landscape keeps the chromatin in a permissive state, which allows rapid transcriptional activation. Additional layers of transcriptional and post-transcriptional control safeguard quiescent stem cells to enable precise stem cell activation when necessary.