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One of four possible MOG subsurface dimers, KTGQF–IENLH is illustrated. The dimers’ accessibility hinges upon disruption of the myelin (oligodendrocyte) cell surface, thus exposing the relevant, subsurface dimer target epitopes. The dimer’s estimated inter-epitope interval distance is 95 Ångströms, and it has a target epitope, KTGQF, which is common to the other three potential sub-surface dimers illustrated in Figure 4.
