Table 1.
Parameters used to simulate exenatide pharmacokineticsa
| Parameter (units) | Description | Value |
|---|---|---|
| Vc (L) | Central volume of distribution | 5.08×10−2 |
| kel (hr−1) | Elimination rate constant for free exenatide | 2.50 |
| kpt (hr−1) | Distribution rate constant | 1.56 |
| ktp (hr−1) | Distribution rate constant | 1.62 |
| kdeg (hr−1) | Degradation rate constant for free receptor | 9.3 ×101 |
| kint (hr−1) | Rate constant of internalization for complex | 1.43×10−1 |
| kon (pM−1·hr−1) | Second-order association rate constant | 1.02×10−3 |
| koff (hr−1) | First-order dissociation rate constant for rat | 3.12×10−3 |
| Rtot (pM) | Receptor concentration at baseline | 5.20×103 |
| Vmax (pmol·hr−1) | Maximum absorption rate for rat | 1.48×104 |
| Km (pmol) | Amount of exenatide when absorption rate is half of the max | 3.41×104 |
a
From Chen et al.13