Table 2.
Final pharmacodynamic model-estimated parameters
| Parameter | Definition | Mean | %RSE | IIV%a | %RSE |
|---|---|---|---|---|---|
| kd (hr−1) | Degradation rate constant of kout | 5.73×10−3 | 30.7 | 44.4 | 76.9 |
| kout0 (hr−1) | Glucose elimination rate constant at baseline | 1.66 | 28.7 | 36.1 | 120 |
| koutss (hr−1) | Glucose elimination rate constant at steady state | 6.19×10−1 | 25.8 | 30.1 | 60.2 |
| S (nM−1·hr−1) | Stimulation index of drug effect on glucose utilization | 2.02×10−4 | 34.4 | 44.4 | 92.4 |
| Glucose baseline_CG (mg/dL) | Glucose baseline for control group | 76 (fixed) | NAb | NA | NA |
| Glucose baseline_T1 (mg/dL) | Glucose baseline for SC infusion group | 79 (fixed) | NA | NA | NA |
| Glucose baseline_T2 (mg/dL) | Glucose baseline for SC injection group | 70 (fixed) | NA | NA | NA |
| Vglu (L/kg) | Volume of distribution of glucose | 2.01×10−1 (fixed) | NA | NA | NA |
| σ | Proportional residual error | 1.21×10−1 | 6.59 | NA | NA |
a
IIV%, inter-individual variability
b
NA, not applicable.