Table IV.

Summary of pharmacokinetic parameters of HCD122 by treatment group.

	0.3 mg/kg (n = 3)	1.0 mg/kg (n = 4)	3.0 mg/kg (n = 8)	4.5 mg/kg (n = 8)	6.0 mg/kg (n = 3)
Half-life, t1/2 (h)
1st infusion, n	0	4	8	8	2
Mean	–	14.542	52.405	108.970	88.676
SD	–	7.719	37.948	80.565	9.726
Median	–	16.731	50.010	85.753	88.676
Minimum	–	4.018	12.986	34.672	81.798
Maximum	–	20.689	102.772	280.430	95.553
4th infusion, n	0	2	5	6	3
Mean	–	20.002	198.474	761.449	175.581
SD	–	16.049	228.381	1502.719	20.810
Median	–	20.002	124.386	157.651	164.531
Minimum	–	8.654	15.487	99.676	162.627
Maximum	–	31.350	575.338	3828.216	199.585
Cmax (μg/mL)
1st infusion, n	3	4	8	8	2
Mean	2.033	14.109	63.963	100.040	125.302
SD	0.874	1.381	23.768	34.388	24.501
Median	2.252	14.246	66.571	97.214	125.302
Minimum	1.070	12.411	24.166	57.540	107.977
Maximum	2.776	15.535	92.471	156.675	142.626
4th infusion, n	3	3	5	6	3
Mean	2.121	15.977	107.033	163.057	213.496
SD	1.388	1.653	55.277	63.476	34.050
Median	2.565	16.929	125.835	145.108	226.962
Minimum	0.566	14.069	24.744	82.726	174.772
Maximum	3.233	16.934	157.348	256.273	238.753
AUC0–168 h (μg•h/mL)
1st infusion, n	3	4	8	8	2
Mean	24.392	463.028	4192.166	7493.302	9687.652
SD	10.487	223.506	2749.109	3510.210	1853.683
Median	27.024	464.066	4144.004	7224.067	9687.652
Minimum	12.840	188.764	636.688	3342.899	8376.900
Maximum	33.312	735.216	7640.840	13 900.435	10 998.404
4th infusion, n	3	3	5	6	3
Mean	39.040	973.100	12 153.413	16 908.049	26 829.964
SD	8.385	521.575	7341.541	8136.447	8284.051
Median	38.796	1095.226	16 942.062	14 717.737	27 513.054
Minimum	30.780	401.298	1125.866	7283.433	18 225.518
Maximum	47.544	1422.776	17 573.372	30 344.744	34 751.321

SD, standard deviation; C_max, drug concentration at end of infusion; AUC, area under the curve.