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MbtA Inhibitors: Linker Domain SAR
| |||
|---|---|---|---|
| Compound, R = | Kiapp (μM) | MIC99 (μM) (iron-poor) | MIC99 (μM) (iron-rich) |
51
|
0.005 ± 0.001 | 0.39 | 1.56 |
52
|
0.004 ± 0.001 | 0.19 | 0.39 |
53
|
0.41 ± 0.06 | > 100 | > 100 |
54
|
3.3 ± 0.6 | 25 | > 100 |
55
|
> 100 | > 100 | > 100 |
56
|
1.25 ± 0.05 | 200 | > 200 |
57
|
143 ± 9 | 100 | > 100 |
